![]() Treatment arm II: Patients receive RT and TMZ alone, followed by maintenance TMZ concomitant with TTFields at 200 kHz to the brain using the Optune®.Īll patients are to receive standard RT and TMZ treatment followed by maintenance TMZ chemotherapy and Optune® according to the current standard of care regimen.Treatment arm I: Patients receive TTFields at 200 kHz to the brain using the Optune® System together with RT and TMZ, followed by maintenance TMZ concomitant with the Optune® treatment.The study will randomize 950 subjects equally to one of two treatment arms: The purpose of the current study is to test if the earlier introduction of Optune®, at the time of radiation therapy (which is given together with temozolomide), improves clinical outcomes compared to the standard of care. The current standard of care for GBM includes the addition of Optune® to maintenance temozolomide (TMZ), following the completion of radiation therapy (RT). Optune® has obtained a CE mark in Europe for recurrent and newly diagnosed GBM. Optune® is a medical device that has been approved for the treatment of recurrent and newly diagnosed glioblastoma (GBM) by the Food and Drug Administration (FDA) in the United States. ![]() Why Should I Register and Submit Results?.Zoonomia Consortium, Zoonomia Consortium Ī genomic timescale for placental mammal evolutionĪ Long-Standing Hybrid Population Between Pacific and Atlantic Herring in a Subarctic Fjord of NorwayĪ Study of the Prevalence of Avian Influenza Viruses and Coronaviruses at Live and Wet Markets in LaosĪbsence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitisĪn Epidemiological Study of Mosquito and Flavivirus Prevalence at Live and Wet Markets in LaosĪn oseltamivir-resistant avian H1N1 influenza A virus can transmit from mallards to chickens similarly to a wild-type strain: implications for the risk of resistance transmission to humansĪntibacterial eremophilane sesquiterpenoids from Xylaria feejeensis, an endophytic fungi of the medicinal plant Geophila repensĪntibiotic interactions: mechanisms and clinical occurrence.Īntibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria: A Swedish longitudinal prospective studyĪntioxidant and Antithrombotic Activities of Kenaf Seed (Hibiscus cannabinus) Coat Ethanol Extract in Sprague Dawley RatsĪssessing compatibility and viral fitness between poultry-adapted H9N2 and wild bird-derived neuraminidasesīayesian mixed model analysis uncovered 21 risk loci for chronic kidney disease in boxer dogsĬalanus helgolandicus: more than a guest in the north?Ĭalcium-responsive plasmid copy number regulation is dependent on discrete YopD domains in Yersinia pseudotuberculosisĬharacterization of Lactic Acid Bacteria and Pathogens Isolated from Traditionally Fermented Foods, In Relation to Food Safety and Antimicrobial Resistance in Tribal Hill Areas of Northeast IndiaĬhiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in MammaliaĬhymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse ModelĬross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosisĭetermination of Growth Rate and Virulence Plasmid Copy Number During Yersinia pseudotuberculosis Infection Using Droplet Digital PCRĭevelopment of High-Throughput Sample Preparation Procedures for the Quantitative Determination of Aflatoxins in Biological Matrices of Chickens and Cattle Using UHPLC-MS/MSĭiscovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosaĮcological adaptation in cod and herring and possible consequences of future climate change in the Baltic SeaĮlucidation of the human adenovirus pVI protein interactomeĮmergence of Highly Pathogenic Avian Influenza A Virus (H5N1) of Clade 2.3.4. A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken
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